Bioavailability issues
Problem: Poor and weak bioavailability issues.
Solution: Liposomal delivery
Liposomes are tiny, protective bubbles that encapsulate active ingredients, shielding
them from stomach acid and digestive enzymes. This innovative technology ensures the
nutrients are safely transported through the bloodstream and delivered directly to your cells, where they can be most effective.
Liposomes enhance the stability of therapeutic compounds, overcoming barriers to cellular and tissue absorption. They also optimize the delivery of these compounds,
ensuring they reach their target sites more effectively
Solving the problem of bioavailability
The purpose of taking supplements is to ensure they are effectively absorbed into the bloodstream through the mucosal membrane and intestinal epithelial cells.
However, traditional oral capsules often face challenges with low absorption and bioavailability. As they pass through the gastrointestinal tract, active ingredients lose a significant portion of their potency or fail to be absorbed in the small intestine altogether. The result? Most of the nutrients are excreted unused through the intestines or kidneys.
Liposomes, made from phospholipids—the fundamental building blocks of cell
membranes—address this issue. Their structure mimics our cell membranes, allowing them to fuse with cells and facilitate the delivery of nutrients that would otherwise be difficult for the body to absorb. This advanced technology ensures optimal absorption and maximum effectiveness.
Targeted Delivery
Liposomal delivery provides targeted, highly efficient absorption of active ingredients, offering a delayed-release effect that sets it apart from other nutrient delivery methods. By extending the circulation time of nutrients in the bloodstream, this advanced
technology dramatically enhances bioavailability. The higher the bioavailability of a compound, the greater its impact on the body, ensuring you get the most out of every
dose.
Understanding the Power of Liposomes
Advanced Absorption
Liposomes are absorbed through the oral mucosal lining and the lymphatic system in the gut,
bypassing the liver’s first-pass metabolism and preventing breakdown. This process preserves
the integrity of the liposomes, allowing them to enter the bloodstream intact. Once inside the
cells, they deliver vitamins, minerals, and micronutrients in a form that’s easier for the body to utilize. This enhanced absorption means greater effectiveness and smaller doses required to achieve superior results.
Biocompatibility
Phospholipids, naturally found in the membranes of cells throughout the body, are recognized as
biocompatible. Because they are seen as familiar and not foreign, the body does not treat them as
harmful or toxic, ensuring no immune response is triggered against the liposome.
Understanding the Power of Liposomes.
Liposomes are absorbed through the oral mucosal lining and the lymphatic system in the gut, by passing the liver’s first-pass metabolism and preventing breakdown. This process preserves the integrity of the liposomes, allowing them to enter the bloodstream intact. Once inside the cells, they deliver vitamins, minerals, and micronutrients in a form that’s easier for the body to utilize. This enhanced absorption means greater effectiveness and smaller doses required to
achieve superior results
Phospholipids, naturally found in the membranes of cells throughout the body, are recognized as biocompatible. Because they are seen as familiar and not foreign, the body does not treat them as harmful or toxic, ensuring no immune response is triggered against the liposome
Liposomes protect nutrients by mimicking biological membranes, allowing them to avoid detection by the body’s immune system and ensuring the active ingredients have more time to reach their target destination. The phospholipid structure helps mask the active ingredients, enabling larger amounts to be absorbed while bypassing the selective filtering of the small intestine. This process also minimizes potential osmotic (hydrophilic) side effects associated with high doses of certain vitamins and minerals, making supplementation more efficient and gentle on the body.
Liposomes have shown the unique ability to cross cellular barriers, allowing them to deliver active ingredients directly into the cells. This process enhances nutrient absorption and ensures efficient circulation through the lymphatic system, maximizing the effectiveness of supplementation
This profound effect of liposome size on complement recognition can also affect liver uptake. Generally, large un-modied liposomes are eliminated more rapidly than small liposomes, which is why our Fluidizing Liposomes™ are very small—less than 100 nm to prevent their uptake by macrophages of the liver and the spleen
What does phosphatidylcholine do?
Phosphatidylcholine (PC) is essential for numerous critical functions in the cardiovascular, reproductive, immune, and nervous systems. PC and its components play a key role in synthesizing prostaglandins—important messenger molecules that regulate muscle contraction and relaxation, among other functions.
Additionally, choline, a component of PC, is vital for producing intracellular messenger molecules and neurotransmitters, which enable nerve cells to communicate with muscles and each other, supporting proper heart and brain function. At birth, up to 90% of cellular membranes are composed of PC. However, as you age, this percentage can decline to as low as 10%. This significant reduction has led many experts to recommend consistent supplementation with this essential phospholipid to maintain optimal health and cellular function.
What are Liposomes made of?
The term liposome originates from the Greek words lipo, meaning fat, and soma, meaning body. Liposomes are spherical, sac-like structures composed of a double layer of fatty acid molecules, specifically phosphatidylcholine—a phospholipid bound to a choline particle. This unique design makes them highly effective for protecting and delivering active ingredients.
The liposomal spherical "sac" is designed to encapsulate and deliver its contents directly into cells and body tissues. Each phospholipid molecule in the liposome consists of a hydrophilic (water-attracting) phosphate head and two hydrophobic (water-repelling) fatty acid tails. This unique structure allows liposomes to carry both water-soluble (hydrophilic) and fat-soluble
(hydrophobic) compounds.
Liposomes are lipid vesicles formed by phospholipids arranged in a double membrane, closely resembling the natural cell membranes in our body. By encapsulating nutrients—such as
NMN—within this protective structure, liposomes enable the active ingredients to bypass the destructive environment of the digestive system. This significantly enhances oral bioavailability and increases peak plasma concentration, ensuring more effective delivery and absorption.
How do Liposomes work?
Liposomes revolutionize nutrient delivery by releasing bioactive compounds through
membrane fusion, signicantly delaying clearance and extending the circulation time of
encapsulated nutrients in the bloodstream. This process enhances retention and
ensures a prolonged, steady release of active ingredients
The interaction between liposomes and cells begins with liposomes adhering to the cell
surface. Once bound, they are internalized into the cell via endocytosis (or
phagocytosis). Inside the cell, the liposome undergoes enzymatic digestion, releasing
its encapsulated nutrients directly into the intracellular environment for optimal
distribution and utilization.
By encapsulating active nutrients, liposomes shield them from premature metabolism,
ensuring they remain inactive until released at the cellular level. The phospholipids in
liposomes bond seamlessly with cell membranes, facilitating ecient intracellular
delivery. This unique ability allows liposomes to bypass the digestive processes that typically break down foreign substances, ensuring the safe and effective delivery of their
cargo.
In essence, liposomes act as advanced carriers, protecting and retaining nutrients
within tissues and cells, maximizing their bioavailability and therapeutic potential. This
cutting-edge technology ensures your body receives the full benets of the nutrients it
needs.
Key Advantages of Liposomal Delivery
Liposomes shield active ingredients from
the harsh environment of the GI tract, signicantly increasing transmucosal (oral)
uptake and absorption.
They optimize the bioavailability of both water-soluble (hydrophilic) and fat-soluble (hydrophobic) compounds, including unstable molecules
Liposomal absorption bypasses digestive processes, eliminating the need to time doses with or without food for optimal results.
Liposomes deliver a higher concentration of nutrients per particle compared to traditional delivery methods.
They offer significantly higher absorption rates and bioavailability than conventional capsules, ensuring more effective nutrient delivery.
Liposomes boost peak plasma levels of encapsulated nutrients, maximizing their therapeutic impact.
